Pathway report - 671682
Source/TargetNodesConfidenceGO AnnotationKEGG AnnotationMSigDB Annotation
PIK3C3 --> CASP3 PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535enzyme inhibitor activity(0.001338)NE(1)REGULATION_OF_DEVELOPMENTAL_PROCESS(1.427e-05)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> BIRC3 -> CASP3 0.587396713382regulation of T cell activation(0.0001291)Apoptosis(6.219e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(7.407e-09)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> BIRC3 -> CASP3 0.587396713382regulation of apoptosis(3.308e-05)Apoptosis(1.271e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(1.483e-09)
ATG16L1 --> CASP3 ATG16L1 -> ATG5 -> DEDD -> CASP8 -> CASP3 0.999972autophagic vacuole(5.631e-07)NE(1)ST_FAS_SIGNALING_PATHWAY(4.634e-08)
PIK3R4 --> CASP3 PIK3R4 -> PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535receptor signaling complex scaffold activity(0.0008176)Regulation of autophagy(0.0009139)UVB_NHEK1_DN(6.485e-06)
AMBRA-1 --> CASP3 AMBRA-1 -> BECN1 -> PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535NE(1)Regulation of autophagy(0.001273)REGULATION_OF_DEVELOPMENTAL_PROCESS(5.57e-07)
ATG12 --> CASP3 ATG12 -> ATG5 -> DEDD -> CASP8 -> CASP3 0.999972autophagic vacuole formation(3.379e-07)Regulation of autophagy(0.0006124)ST_FAS_SIGNALING_PATHWAY(4.634e-08)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> BIRC3 -> CASP3 0.587396713382regulation of apoptosis(8.145e-05)Apoptosis(3.143e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.705e-09)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338891775545688regulation of T cell activation(0.0001291)Apoptosis(6.792e-07)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.71e-12)
BECN1 --> CASP3 BECN1 -> PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535regulation of apoptosis(0.0001604)Regulation of autophagy(0.0009139)REGULATION_OF_DEVELOPMENTAL_PROCESS(2.409e-07)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338891775545688NE(1)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ATG10 --> CASP3 ATG10 -> ATG5 -> DEDD -> CASP8 -> CASP3 0.999972autophagy(2.533e-06)NE(1)ST_FAS_SIGNALING_PATHWAY(4.634e-08)
DAPK1 --> CASP3 DAPK1 -> BECN1 -> PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535regulation of apoptosis(5.66e-06)Regulation of autophagy(0.001273)REGULATION_OF_DEVELOPMENTAL_PROCESS(3.79e-09)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338891775545688NE(1)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> BIRC3 -> CASP3 0.587396713382regulation of T cell activation(0.0001291)Apoptosis(6.219e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(7.407e-09)
ATG5 --> CASP3 ATG5 -> DEDD -> CASP8 -> CASP3 0.999972induction of apoptosis via death domain receptors(2.229e-06)Apoptosis(0.001296)ST_FAS_SIGNALING_PATHWAY(1.856e-08)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338891775545688autophagy(5.315e-06)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
*Paths limited to 15 edges